Cancer Therapy: Preclinical Cross-talk between EphA2 and BRaf/CRaf Is a Key Determinant of Response to Dasatinib
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چکیده
Purpose: EphA2 is an attractive therapeutic target because of its diverse roles in cancer growth and progression. Dasatinib is a multikinase inhibitor that targets EphA2 and other kinases. However, reliable predictive markers and a better understanding of the mechanisms of response to this agent are
منابع مشابه
Cross-talk between EphA2 and BRaf/CRaf is a key determinant of response to Dasatinib.
PURPOSE EphA2 is an attractive therapeutic target because of its diverse roles in cancer growth and progression. Dasatinib is a multikinase inhibitor that targets EphA2 and other kinases. However, reliable predictive markers and a better understanding of the mechanisms of response to this agent are needed. EXPERIMENTAL DESIGN The effects of dasatinib on human uterine cancer cell lines were ex...
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تاریخ انتشار 2014